University of Sheffield

PhD Studentship (Hyperpolarized xenon MRI)
Imaging for Cancer Research
School of Medicine & Biomedical Sciences, Academic Unit of Surgical Oncology
Start Date: October 2009Funding: 4 Years at the Current Cancer Research UK rate
Applications are invited for two PhD studentships to join a consortium of multi-disciplinary investigators working on a new initiative funded by Cancer Research UK & EPSRC, in association with the MRC and Department of Health (England), for development of new techniques in magnetic resonance and spectroscopy imaging (MRI & MRSI) and matrix-assisted laser desorption ionization mass spectrometry imaging (MALDI-MSI), as bio-markers for clinical development of tumour vascular-targeting agents. These agents form a new class of anti-cancer agents that complement existing treatments, such as chemo- and radio-therapy. For further information on vascular targeting see:www.shef.ac.uk/medicine/research/sections/oncology/surgical-oncology/unitresearch/tmg
PhD studentship (Hyperpolarized xenon MRI): The group has a strong international track record in hyperpolarized gas MRI for lung imaging - Here, we will develop similar techniques with 129Xe MRI for investigation of blood flow rate and the tumour microenvironment. A strong first degree in a physical science and a strong interest in biological and medical application are essential. Some experience of NMR/MRI and/or biology would be useful but not essential. Further information from Dr Jim Wild (j.m.wild@sheffield.ac.uk): www.shef.ac.uk/medicine/research/sections/endo-repro/radiology/research/intro.html
PhD studentship (Nano-particles): The group has a strong international track record in development of molecularly-targeted polymer nano-particles - Here, we will develop such an approach to investigate tumour vascular maturity/treatment susceptibility for use with MRI. Initial experiments will be carried out using optical imaging. A strong first degree is essential, preferably in bioengineering, medical physics, pharmacy or similar, although life sciences graduates with a strong interest in nano-technology will also be considered. Further information from Dr Giuseppe Battaglia (g.battaglia@sheffield.ac.uk): www.sheffield.ac.uk/materials/staff/gbattaglia.html
Candidates may apply for one or both positions. Studentships will start in October 2009 for 4 years, with a stipend at current Cancer Research UK rates.
How to Apply
Please complete a University Postgraduate Research Application form and provide at least two references. To download the application form please visit: www.shef.ac.uk/postgraduate/research/apply/pgrform.html.
Please clearly state ‘Medicine' and the prospective main supervisor in the respective boxes. If you have any queries on how to apply contact Ms Sara Watkinson (s.watkinson@sheffield.ac.uk).