Department of Pharmacy & Pharmacology — University of Bath

PhD studentship
Pharmaceutics
Department of Pharmacy & Pharmacology
A PhD Studentship is available immediately with the aim to identify biopharmaceutical issues that have impact in preclinical and clinical study design and to develop in vitro-in vivo correlations (IVIVCs) for orally administered formulations (supervised by Dr Nikoletta Fotaki).
The Department of Pharmacy and Pharmacology at the University of Bath is a top rated, internationally renowned Department (RAE 5*A) that is committed to supporting excellence in research.
A PhD studentship is offered within the area of Pharmaceutics.
Oral drug absorption is a dynamic complex process comprising of several competitive components. Understanding and anticipating the mechanisms and factors affecting the absorption are of great importance for the pharmaceutical sciences as in this way precise in vitro techniques can be designed for the prediction of the oral drug absorption. As most formulations are administered in solid form, the dissolution process is one of the important limiting steps for the entire absorption process.
Formulations in which the drug is incorporated in the amorphous state have drawn the attention of pharmaceutical scientists lately. These formulations can be a possible solution to overcome the problem of the poor solubility that most of the new chemical entities present, as the amorphous state present higher solubility and dissolution rate compared with the crystalline state. Characterisation of their dissolution performance in conditions which are relevant to in vivo conditions is crucial in order to evaluate behaviour during dissolution and to predicting in vivo performance.
The study aims to identify biopharmaceutical issues that have impact in preclinical and clinical study design and to develop in vitro-in vivo correlations (IVIVCs) for these formulations.
The studentship is for 3 years.
If you would like to express your interest by sending a CV and to discuss the research area, please contact Dr Nikoletta Fotaki [Tel: +44 (0)1225 386728, e-mail: n.fotaki@bath.ac.uk]
Application details: http://www.bath.ac.uk/pharmacy/postgraduates/howtoapplyres.html